Human Recombinant Tau-441 (2N4R) P301S Mutant Pre-formed Fibrils (CHO-expressed, N-glycosylated)
官网链接
折扣/货期| 货号：SPR-516C | 规格：100 µg x2 | 目录价：￥18963 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
Human Recombinant Tau-441 (2N4R) P301S Mutant Pre-formed Fibrils (CHO-expressed, N-glycosylated)
别名:
MAPT, intracellular neurofibrillary tangles, NFTs, paired helical filaments, PHFs, 2N4R
产品描述:
Human Recombinant Tau-441 (2N4R) P301S Mutant Pre-formed Fibrils (CHO-expressed, N-glycosylated)
反应种属:
Human
实验应用:
WB | In vivo Assay | In vitro Assay
纯化方式:
Affinity Purified and Size Exclusion
偶联:
N-term histidine tag & TEV site
产品浓度:
2 mg/ml or 5 mg/ml
表达系统:
Chinese Hamster Ovary (CHO)
保存温度:
-80ºC
运输温度:
Dry Ice. Shipping note: Product will be shipped separately from other products purchased in the same order.
预期分子量:
48.609 kDa
存储溶液:
1X PB pH7.4, 2mM DTT
产地:
加拿大
功能与背景:
Mammalian N-glycosylation is present on CHO-secreted tau 2N4R, which contributes to slower migration on SDS-PAGE than E.coli or Baculovirus/Sf9 expressed tau (1, 2). N-glycosylated tau has been identified in human AD-diseased brains, but not healthy brains, and may precede tau hyperphosphorylation (3, 4). N-glycosylation of Tau has been demonstrated to affect its aggregation propensity (5). The tau P301S mutation is associated with early onset neurodegeneration, and functionally reduces microtubule assembly and stimulates fibril assembly (6, 7). Our CHO-expressed Tau 2N4R P301S will readily form fibrils in the absence of heparin and contains mammalian post-translational modifications that may better mimic tau in human AD-brains.
纯度:
>95%
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