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折扣/货期| 货号：AG-CR1-3665-M005 | 规格：5 mg | 目录价：￥960 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
INDY
别名:
(1Z)-1-(3-Ethyl-5-hydroxy-2(3H)-benzothiazolylidene)-2-propanone
产品描述:
Potent and selective ATP-competitive DYRK1A and DYRK1B inhibitor (IC50=240nM and 230nM respectively). Binds at the ATP-binding cleft of the enzyme. Inhibits also DYRK2, DYRK3, CLK1, CLK4, casein kinase 1 (CSNK1D) and PIM1 (>90% inhibition at the same concentration). Reverses aberrant tau-phosphorylation and rescues repressed calcineurin/NFAT signaling. Impairs the self-renewal capacity of neural stem cells and glioblastoma tumor-initiating cells. Shown to induce regeneration and expansion of rat and adult human beta-cells in vivo or ex vivo.
保存温度:
+4°C
运输温度:
Ambient
预期分子量:
235.3
产品形式:
solid
有效期:
Stable for at least 2 years after receipt when stored at -20°C.
产地:
瑞士
纯度:
>98% (HPLC)
CAS号:
1169755-45-6
分子式:
C12H13NO2S
溶解度:
Soluble in DMSO (10mg/ml).
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