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折扣/货期| 货号：AG-CR1-3663-M001 | 规格：1 mg | 目录价：￥1080 |
| 货号：AG-CR1-3663-M005 | 规格：5 mg | 目录价：￥4080 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
A-443654
别名:
(S)-1-(1H-Indol-3-yl)-3-((5-(3-methyl-1H-indazol-5-yl)pyridin-3-yl)oxy)propan-2-amine
产品描述:
Potent and selective Akt inhibitor (Ki=160pmol/L for all three isoforms PKBalpha, PKBbeta and PKBgamma). DYRK1A inhibitor (IC50=10nM). Inhibits other kinases, including PRK2, MSK1 and DYRK3 at low nM range as well. Interferes with mitotic progression by regulating aurora a kinase expression and bipolar spindle formation. It induces G2/M accumulation, defects in centrosome separation and formation of either monopolar arrays or disorganized spindles. Anticancer agent. Apoptosis inducer and chemosensitizing agent. Slows the progression and growth of Akt-dependent tumors. Induces rapid Akt Ser473 phosphorylation independent of mTORC1 inhibition in human cancer cell lines. Activates mTORC2 and reverses long-term memory deficits.
保存温度:
+4°C
运输温度:
Ambient
预期分子量:
397.5
产品形式:
solid
有效期:
Stable for at least 2 years after receipt when stored at -20°C.
产地:
瑞士
纯度:
>98%
CAS号:
552325-16-3
分子式:
C24H23N5O
溶解度:
Soluble in DMSO (15mg/ml), ethanol (10mg/ml) or DMF (20mg/ml).
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