官网链接
折扣/货期| 货号：96-461 | 规格：0.02 mg | 目录价：￥6405.75 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
Interleukin 1b Recombinant Protein
别名:
IL1B, IL-1BETA, IL1F2, IL-1β
实验应用:
WB
表达系统:
E. coli
保存温度:
Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.
运输温度:
Blue Ice
产品形式:
Lyophilized
存储溶液:
PBS, pH7.4
产地:
美国
生产商:
Prosci
功能与背景:
Interleukin-1 beta (IL-1β) is also known as catabolin, is a cytokine protein that in humans is encoded by the IL1B gene. IL-1β precursor is cleaved by caspase 1 (interleukin 1 beta convertase). Cytosolic thiol protease cleaves the product to form mature IL-1 beta.
IL1β are structurally related polypeptides that share approximately 21% amino acid (aa) identity in human. Both proteins are produced by a wide variety of cells in response to inflammatory agents, infections, or microbial endotoxins. While IL1α and IL1β are regulated independently, they bind to the same receptor and exert identical biological effects.
IL-1β is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2.
纯度:
>97% as determined by SDS-PAGE.
生物活性:
The bio-activity was determined by dose-dependent stimulation of the proliferation of mouse D10. G4. 1 cells. The ED50 < 2 pg/mL, corresponding to a specific activity of >500,000,000 Unit/mg.
Accession #:
NP_000567
您可能感兴趣的产品
Histone H3 (human, recombinant)
货号：10263-1 mg
Influenza B Strain B/Hong Kong 5/72 Antigen
货号：11-576
TMIGD2 Recombinant Protein
货号：RF16120-01
TIM3 Recombinant Protein
货号：RF16100-01
B7-H3 Recombinant Protein
货号：RF16090-01
LAG-3 Recombinant Protein
货号：RF16080-01
B7-H5 Recombinant Protein
货号：RF16070-01
LIGHT Recombinant Protein
货号：RF16060-01
促销活动
复制QQ号成功，请打开QQ后添加好友进行咨询