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折扣/货期| 货号：CDX-J0001-M050 | 规格：50 mg | 目录价：￥672 |
| 货号：CDX-J0001-M200 | 规格：200 mg | 目录价：￥2058 |
| 货号：CDX-J0001-GG25 | 规格：2.5 g | 目录价：￥12768 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
Josamycin
别名:
Kitasamycin A3; Leucomycin A3; Turimycin A5
产品描述:
Josamycin is a member of the leucomycin family of macrolide antibiotics produced by Streptomyces kitasatoensis. It is an antimicrobial against a wide variety of pathogens. It has activity against Gram-positive an Gram-negative bacteria. The mechanism of action is via inhibition of bacterial protein biosynthesis by binding reversibly to the subunit 50S of the bacterial ribosome, inhibiting peptidyltransferase and ribosomal translocation, thereby inhibiting translocation of peptidyl tRNA. Josamycin may overcome anticancer drug resistance by inhibiting the binding of vinblastine or cyclosporin A to P-glycoprotein (Pgp). It is used to study the modification of phagocytosis and cytokine production by macrolide antibiotics and immunomodulatory effects.
宿主来源:
Isolated from Streptomyces narbonensis var. josamyceticus var. nova.
保存温度:
+4°C
运输温度:
Ambient
预期分子量:
827.99
产品形式:
solid
有效期:
Stable for at least 2 years after receipt when stored at +4°C.
产地:
瑞士
纯度:
>90% (HPLC)
CAS号:
16846-24-5
分子式:
C42H69NO15
溶解度:
Soluble in ethanol (25mg/ml), DMSO (15mg/ml) or DMF (25mg/ml). Sparingly soluble in water (0.05mg/ml).
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