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折扣/货期| 货号：AG-CP3-0045-M001 | 规格：1 mg | 目录价：￥720 |
| 货号：AG-CP3-0045-M005 | 规格：5 mg | 目录价：￥2520 |
| 货号：AG-CP3-0045-M025 | 规格：25 mg | 目录价：￥5400 |
| 货号：AG-CP3-0045-M100 | 规格：100 mg | 目录价：￥13200 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
Mazdutide
别名:
LY3305677; LY-3305677; IBI362
产品描述:
Mazdutide is a novel long-acting dual glucagon-like peptide-1 (GLP-1) receptor and glucagon receptor (GCGR) agonist. Mazdutide potently activates the GLP-1R signaling pathway to stimulate glucose-dependent insulin secretion through activity at the GCG receptor (GCGR) or the GLP-1R. Mazdutide is a synthetic peptide analog of the gut peptide hormone oxyntomodulin that reduces body weight in both Gcgr-/- and Glp1r-/- mice. Mazdutide binds human and mouse GCGR (Ki: 17.7nM and 15.9nM, respectively) and GLP-1R (Ki: 28.6nM and 25.1nM, respectively) and stimulates insulin secretion from mouse islets (EC50: 5.2 nM). Mazdutide is used in studies of obesity and type 2 diabetes (T2D) and is designed enhancing energy expenditure and fat metabolism. Mazdutide comprises a 33 amino acid linear synthetic peptide conjugated to a C20 fatty diacid moiety through a hydrophilic linker at the lysine residue at position 20. Due to this moiety, the compound is highly bound to albumin in the plasma which prolongs its half-life. It contains one non-coded amino acid residue (Aib, alpha-amino isobutyric acid) at position 2.
宿主来源:
Synthetic.
保存温度:
+4°C
运输温度:
Ambient
预期分子量:
4563.1
产品形式:
solid
产地:
瑞士
纯度:
>98% (HPLC)
CAS号:
2259884-03-0
分子式:
C210H322N46O67
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