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折扣/货期| 货号：SIH-617-5MG | 规格：5 mg | 目录价：￥1396.8 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
ML133 HCl
别名:
N-[(4-Methoxyphenyl)methyl]-1-naphthalenemethanamine, hydrochloride
产品描述:
Potassium channel Blocker- Neuroprotective
保存温度:
-20ºC
运输温度:
Shipped Ambient
预期分子量:
313.8
产品形式:
White powder
产地:
加拿大
功能与背景:
A potent and selective blocker of the inwardly rectifying Kir2 potassium channel, IC50s = 1.8, 2.8, 2,9, and 4.0 µM for Kir2.1, Kir2.6, Kir2.2, and Kir2.3, respectively (1). Intrathecal injection of ML133 attenuated the proliferation of microglia and neuropathic pain behaviors after nerve injury (2). ML133 inhibits microglial priming pointing to Kir2.1 channels as a new therapeutic target for neuronal damage (3). Moreover, treatment with ML133 one hour post-injury was sufficient to improve neuronal survival in a traumatic brain injury human organoid model (4).
纯度:
>98% (HPLC); NMR (Conforms)
来源:
Synthetic
CAS号:
1222781-70-5
分子式:
C19H19NO • HCl
溶解度:
May be dissolved in DMSO (32 mg/ml); or water (10 mg/ml, warm)
PubChem CID:
44247466
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