MyD88 Fragment Recombinant Protein-其他重组蛋白-深圳欣博盛生物科技有限公司

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MyD88 Fragment Recombinant Protein

品牌：ProSci LLC

官网链接

说明书

折扣/货期

货号：95-104

规格：0.05 mg

目录价：￥4226.625

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

MyD88 Fragment Recombinant Protein

别名:

MyD88 Antibody : MYD88D

实验应用:

ELISA,WB

表达系统:

E. coli

保存温度:

Store in working aliquots at -70˚C. Avoid freeze/thaw cycles. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.

运输温度:

Dry Ice

产品形式:

Liquid

存储溶液:

1X PBS containing 0.1% SDS and 0.02% NaN₃

产地:

美国

生产商:

Prosci

功能与背景:

The pro-inflammatory cytokine IL-1 induced cellular response requires IL-1 receptor complex including IL-1RI and IL-1RAcP. MyD88 has been identified as an adapter molecule in the IL-1 signaling pathway (1). MyD88 associates with and recruits IRAK to the IL-1 receptor complex in response to IL-1 treatment and dominant negative form of MyD88 attenuates IL-1R-mediated NF-B activation. MyD88 is also employed as a regulator molecule by IL-18 receptor and human Toll receptor (2,3), which are members in the Toll/IL-1R family of receptors. Targeted disruption of the MyD88 gene results in lose of cellular responses to IL-1 and IL-18, and MyD88-deficient mice lack responses to bacterial product LPS that employs Toll-like receptors 2 and 4 (TLR2 and TLR4) as the signaling receptors. MyD88 is a general adapter protein for the Toll/IL-1R family of receptors and plays an important role in the inflammatory response induced by cytokines IL-1 and IL-18 and endotoxin. MyD88 gene is expressed in many tissues.

纯度:

~95%

Accession #:

AAC50954

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