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折扣/货期| 货号：AG-CN2-0307-M001 | 规格：1 mg | 目录价：￥1080 |
| 货号：AG-CN2-0307-M005 | 规格：5 mg | 目录价：￥4320 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
NAI-107 [Microbisporicin]
别名:
Lantibiotic NAI 107; Lantibiotic 107891; MicrobisporicinA1/A2 Mixture (~75%:25%)
产品描述:
Antibacterial class I lantibiotic. Mixture of two similarly active and structurally related polypeptides (A1, 2246Da and A2, 2230Da) of 24 amino acids linked by 5 intramolecular thioether bridges. Inhibits cell wall synthesis and consequently bacterial growth by forming a complex with lipid intermediate II (Lipid II), a key intermediate in peptidoglycan biosynthesis. Efficiently interferes with late stages of cell wall biosynthesis leading to accumulation of the soluble peptidoglycan precursor UDP-N-acetylmuramic acid-pentapeptide (UDP-MurNAc-pentapeptide) in the cytoplasm. Active against aerobic and anaerobic Gram-positive pathogens, including all antibiotic-resistant strains (e.g. MRSA and VRE) in whole cell and in vitro assays as well as in vivo. Rapidly bactericidal and highly efficacious in experimental models of infection (septicemia, endocarditis, granuloma pouch) and developed for treatment of serious infections by multidrug-resistant Gram-positive bacteria.
宿主来源:
Isolated from Microbispora sp.
保存温度:
+4°C
运输温度:
Ambient
预期分子量:
2249.0 (A1; R=OH)2233.0 (A2; R=H)
产品形式:
solid
有效期:
Stable for at least 2 years after receipt when stored at -20°C.
产地:
瑞士
纯度:
>80% (HPLC, for A1/A2)
CAS号:
845293-74-5 [A1/A2 Mixture]
分子式:
C94H127ClN26O27S5 (A1)
C94H127ClN26O26S5 (A2)
溶解度:
Soluble in DMSO, aqueous acetonitrile or ethanol.
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