NCC Antibody: ATTO 594-多抗-深圳欣博盛生物科技有限公司

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NCC Antibody: ATTO 594

品牌：Stressmarq

官网链接

说明书

折扣/货期

货号：SPC-402D-A594

规格：100 µg

目录价：￥5065.2

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

NCC Antibody: ATTO 594

别名:

SLC12A3 Antibody, SCYL1 Antibody,CKb10 Antibody, MCP-4 Antibody, MGC17134 Antibody, NCC-1 Antibody, NCC1 Antibody, SCYA13 Antibody, CK-beta-10 Antibody, monocyte chemoattractant protein 4 Antibody, monocyte chemotactic protein 4 Antibody, new CC chemokine 1 Antibody, small inducible cytokine A13 Antibody, small inducible cytokine subfamily A (Cys-Cys) member 13 Antibody, chemokine (C-C) Antibody

产品描述:

Rabbit Anti-Rat NCC Polyclonal

反应种属:

Human | Mouse | Rat | Dog

宿主来源:

Rabbit

实验应用:

WB | IHC | ICC/IF | IEM

靶标/特异性:

Detects ~160kDa.

推荐稀释度:

WB (1:1000), IHC (1:200); optimal dilutions for assays should be determined by the user.

免疫原:

Produced against a synthetic peptide mapping to a segment of rat NCC (amino acids 74-95), N-terminal

免疫原种属:

Rat

克隆性:

Polyclonal

纯化方式:

Affinity Purified

偶联:

ATTO 594

产品浓度:

1 mg/ml

保存温度:

Conjugated antibodies should be stored according to the product label

运输温度:

Blue Ice or 4ºC

存储溶液:

PBS, 50% glycerol, 0.09% sodium azide *Storage buffer may change when conjugated

产地:

加拿大

功能与背景:

NCC, a thiazide-sensitive NaCl co-transporter, is found on the apical membrane of the distal convoluted tubule, where it is the principal mediator of Na+ and Cl- reabsorption in this segment of the nephron. It is activated by phosphorylation, and has been implicated in renal NaCl and K+ homeostasis (1). Regulation of NCC expression and phosphorylation by dietary NACl restriction appears to involve SGK1(1). In experiments with angiotensin II-infused mice, increased sensitivity to Ang II may involved over-activity of NCC (2). Therefore, NCC is the target of thiazide diuretics used in the treatment of hypertension (1). Molecular experiments have also shown that NCC has been detected in the lens cortex, core and fiber cells of a rat (3).

Accession #:

NP_062218, NP_000330