Nitrotyrosine Antibody: RPE-单抗-深圳欣博盛生物科技有限公司

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Nitrotyrosine Antibody: RPE

品牌：Stressmarq

官网链接

说明书

折扣/货期

货号：SMC-154D-RPE

规格：100 µg

目录价：￥5052.6

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

Nitrotyrosine Antibody: RPE

别名:

Nitro tyrosine Antibody, 3-Nitrotyrosine Antibody

产品描述:

Mouse Anti- Nitrotyrosine Monoclonal IgG2a

反应种属:

Species Independent

宿主来源:

Mouse

实验应用:

WB | IHC | ICC/IF | IP | ELISA | FCM | AM

靶标/特异性:

Recognizes 3-nitrotyrosine moieties. No detectable cross-reactivity with non-nitrated tyrosine. Not species specific.

同种型:

IgG2a

推荐稀释度:

WB (1:1400), IHC (1:100); optimal dilutions for assays should be determined by the user.

免疫原:

3-(4-hydroxy-3-nitrophenylacetamido) propionic acid-bovine serum albumin

克隆性:

Monoclonal

克隆号:

39B6

纯化方式:

Protein G Purified

偶联:

RPE

产品浓度:

1 mg/ml

保存温度:

Conjugated antibodies should be stored according to the product label

运输温度:

Blue Ice or 4ºC

存储溶液:

PBS, 50% glycerol, 0.09% sodium azide *Storage buffer may change when conjugated

产地:

加拿大

功能与背景:

Protein tyrosine nitration results in a post-translational modification that is increasingly receiving attention as an important component of nitric oxide signaling (2). While multiple nonenzymatic mechanisms are known to be capable of producing nitrated tyrosine residues, most tyrosine nitration events involve catalysis by metalloproteins such as myeloperoxidase, eosino-philperoxidase (3), myoglobin, the cytochrome P-450s, superoxide dismutase and prostacyclin synthase. Nitrotyrosine may also serve as a biomarker for the effects of reactive nitrogen oxides, based on tyrosine residues becoming nitrated in proteins at sites of inflammation induced tissue injury (1). The presence of nitro tyrosine-containing proteins therefore has shown high correlation to disease states such as atherosclerosis, Alzheimer's disease, Parkinson's disease and amyotrophic lateral sclerosis (4).