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折扣/货期| 货号：PM-4913-0.02 mg | 规格：0.02 mg | 目录价：￥1345.5 |
| 货号：PM-4913-0.1 mg | 规格：0.1 mg | 目录价：￥6084 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
ORAI3 Antibody [1B4F1]
别名:
ORAI3 Antibody [1B4F1] : TMEM142C
反应种属:
Human,Rat
宿主来源:
Mouse
实验应用:
ELISA,WB
同种型:
IgG2b
克隆性:
Monoclonal
克隆号:
1B4F1
纯化方式:
ORAI3 Monoclonal Antibody is immunoaffinity chromotography purified IgG.
偶联:
Unconjugated
产品浓度:
1 mg/mL
保存温度:
ORAI3 monoclonal antibody can be stored at -20˚C, stable for one year.
运输温度:
Blue Ice
产品形式:
Liquid
存储溶液:
ORAI3 Monoclonal Antibody is supplied in PBS containing 0.02% sodium azide.
产地:
美国
生产商:
Prosci
功能与背景:
ORAI3 Monoclonal Antibody: Antigen stimulation of immune cells triggers Ca++ entry t hrough Ca++ release-activated Ca++ (CRAC) channels. ORAI3 is one of two mammalian homologs to ORAI1, a recently identified four-transmembrane spanning protein that is an essential component of CRAC. All three homologs have been shown to function as Ca++ plasma membrane channels gated through interactions with STIM1, the store-activated endoplasmic reticulum Ca++ sensor. However, ORAI3 channels failed to produce detectable Ca++ selective currents in cells co-transfected with ORAI3 and STIM1, indicating that ORAI3 channels undergo a lesser degree of depotentiation than ORAI1 or ORAI2. Na+ currents through ORAI1, 2 and 3 channels were equally inhibited by extracellular Ca++, indicating that each have similar affinities for Ca++ within the selectivity filter. This antibody is predicted to have no cross-reactivity to ORAI1 or ORAI2. Larger molecular weight bands are sometimes seen in SDS-PAGE; these may represent post-translationally modified ORAI 3.
Accession #:
Q9BRQ5
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