官网链接
折扣/货期| 货号：CDX-O0202-M025 | 规格：25 mg | 目录价：￥4060 |
| 货号：CDX-O0202-M100 | 规格：100 mg | 目录价：￥12166 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
Orantinib
别名:
TSU68; SU 6668; NSC 702827; 5-[1,2-Dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-propanoic acid
产品描述:
Orantinib is an orally bioavailable receptor tyrosine kinase inhibitor. Orantinib binds to and inhibits the autophosphorylation of vascular endothelial growth factor receptor 2 (VEGFR2), platelet-derived growth factor receptor (PDGFR), and fibroblast growth factor receptor (FGFR), thereby inhibiting angiogenesis and cell proliferation. It is a potent ATP-competitive inhibitor of PDGFRbeta, VEGFR2, and FGFR1 (IC50 = 0.06, 2.4, and 3.0 µM, respectively) but not EGFR (IC50 >100 µM). Orantinib suppresses tumor growth, blocks angiogenesis in tumors and induces apoptosis of tumor vasculature and regression of established tumors. Orantinib inhibits the phosphorylation of the stem cell factor receptor tyrosine kinase c-kit, often expressed in acute myelogenous leukemia cells, inhibits Aurora kinases B and C (IC50=35 and 210nM, respectively), and inhibits Unc-51-like serine/threonine kinase Ulk3, involved in hedgehog signaling. All together ornatinib exhibits antiangiogenic, anti-inflammatory, antimetastatic and proapoptotic activity.
保存温度:
-20°C
运输温度:
Ambient
预期分子量:
310.35
产品形式:
solid
产地:
瑞士
纯度:
>98% (HPLC)
CAS号:
252916-29-3
分子式:
C18H18N2O3
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