Oridonin-其他小分子化合物-深圳欣博盛生物科技有限公司

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Oridonin

品牌：Adipogen

官网链接

说明书

折扣/货期

货号：CDX-O0131-M005	规格：5 mg	目录价：￥644
货号：CDX-O0131-M025	规格：25 mg	目录价：￥2212

产品详情

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产品名称:

Oridonin

别名:

7alpha,20-Epoxy-1alpha,6beta,7,14-tetrahydroxy-Kaur-16-en-15-one, NSC 250682

产品描述:

Oridonin is a diterpenoid that has been found in R. rubescens and has anti-inflammatory and anticancer, antimicrobial and neuroprotective properties. The regulatory anticancer mechanisms include induction of apoptosis and autophagy, inhibition of proliferation, inhibition of angiogenesis, cell cycle arrest. It is an inhibitor of the TLR4/p38-MAPK and TLR4/NF-kappa signaling pathways and PPARgamma. Oridonin is a high affinity inhibitor of NLRP3 inflammasome assembly and activation (Kd = 52.5 nM). It inhibits inflammation in wild-type, but not Nlrp3-/-, mice in a model of high-fat diet-induced type 2 diabetes. Also inhibits glial activation, decreases inflammatory cytokine release, attenuates synaptic loss and improves behavioural deficits in Abeta1-42 treated mice. CRL/SCF RING E3 inhibitor. Inhibits Fbw7 an E3 ubiquitin ligase (CRL/SCF RING) of c-Myc and promotes proteasomal degradation.

宿主来源:

Plant

保存温度:

+20°C

运输温度:

Ambient

预期分子量:

364.43

产品形式:

solid

产地:

瑞士