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折扣/货期| 货号：CDX-O0131-M005 | 规格：5 mg | 目录价：￥630 |
| 货号：CDX-O0131-M025 | 规格：25 mg | 目录价：￥2128 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
Oridonin
别名:
7alpha,20-Epoxy-1alpha,6beta,7,14-tetrahydroxy-Kaur-16-en-15-one, NSC 250682
产品描述:
Oridonin is a diterpenoid that has been found in R. rubescens and has anti-inflammatory and anticancer, antimicrobial and neuroprotective properties. The regulatory anticancer mechanisms include induction of apoptosis and autophagy, inhibition of proliferation, inhibition of angiogenesis, cell cycle arrest. It is an inhibitor of the TLR4/p38-MAPK and TLR4/NF-kappa signaling pathways and PPARgamma. Oridonin is a high affinity inhibitor of NLRP3 inflammasome assembly and activation (Kd = 52.5 nM). It inhibits inflammation in wild-type, but not Nlrp3-/-, mice in a model of high-fat diet-induced type 2 diabetes. Also inhibits glial activation, decreases inflammatory cytokine release, attenuates synaptic loss and improves behavioural deficits in Abeta1-42 treated mice. CRL/SCF RING E3 inhibitor. Inhibits Fbw7 an E3 ubiquitin ligase (CRL/SCF RING) of c-Myc and promotes proteasomal degradation.
宿主来源:
Plant
保存温度:
+20°C
运输温度:
Ambient
预期分子量:
364.43
产品形式:
solid
有效期:
Stable for at least 2 years after receipt when stored at +4°C.
产地:
瑞士
纯度:
>98% (HPLC)
CAS号:
28957-04-2
分子式:
C20H28O6
溶解度:
Soluble in DMSO (20mg/ml), DMF (20mg/ml) or ethanol (20mg/ml). Insoluble in water.
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