p16-INK4a-TAT Recombinant Protein-其他重组蛋白-深圳欣博盛生物科技有限公司

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p16-INK4a-TAT Recombinant Protein

品牌：ProSci LLC

官网链接

说明书

折扣/货期

货号：40-527-0.005 mg	规格：0.005 mg	目录价：￥3783
货号：40-527-0.025 mg	规格：0.025 mg	目录价：￥5674.5

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

p16-INK4a-TAT Recombinant Protein

别名:

ARF, MLM, P14, P16, P19, CMM2, INK4, MTS1, TP16, CDK4I, CDKN2, INK4A, MTS-1, P14ARF, P19ARF, P16INK4, P16INK4A, P16-INK4A, Cyclin-dependent kinase 4 inhibitor A

表达系统:

E. coli

保存温度:

The lyophilized p16-INK4a-TAT recombinant protein is stable for at least 2 years from date of receipt at -20˚C. Reconstituted p16-INK4a-TAT is stable for at least 3 months when stored in working aliquots with a carrier protein at -20˚C. As with any protein, exposing p16-INK4a-TAT recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.

运输温度:

Blue Ice

产品形式:

Lyophilized

产地:

美国

生产商:

Prosci

功能与背景:

p16-INK4a is a nuclear protein that regulates the cell cycle by inhibiting cyclin dependent kinase-4 (CDK4) and CDK6. p16-INK4a inhibits CDK activity by binding to the CDK molecules in a manner that interferes with their ability to interact with cyclin D. This activity has the effect of suppressing tumor formation and growth, and of inducing replicative senescence in various normal cells, including stem cells. The expression of p16-INK4a steadily increases with age and tends to accumulate in stem cell compartments. The deletion, rearrangement, or mutation of the p16-INK4a gene is frequently found in melanomas as well as in certain other types of cancer. P16-INK4a and other transcription factors have been introduced into cells by DNA transfection, viral infection, or microinjection. Protein transduction using TAT fusion proteins represents an alternative methodology for introducing transcription factors and other nuclear proteins into primary as well as transformed cells. Recombinant human p16-INK4a-TAT expressed in E. coli is a 18 kDa protein containing 167 amino-acid residues, including the 156 residues of full-length p16-INK4a and a 13-residue C-terminal TAT peptide (GGYGRKKRRQRRR).

纯度:

Greater than or equal to 95% by SDS-PAGE gel and HPLC analyses.

生物活性:

Endotoxin level is less than 0.1 ng per ug (1EU/μg).

Accession #:

NP_000068.1

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