PDI Antibody: FITC-多抗-深圳欣博盛生物科技有限公司

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PDI Antibody: FITC

品牌：Stressmarq

官网链接

说明书

折扣/货期

货号：SPC-114D-FITC

规格：100 µl

目录价：￥4863.6

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

PDI Antibody: FITC

别名:

PDI Antibody, PDIA1 Antibody, PDIP Antibody, pancreatic protein disulfide isomerase Antibody

产品描述:

Rabbit Anti-Rat PDI Polyclonal

反应种属:

宿主来源:

Rabbit

实验应用:

WB | IHC | ICC/IF | IP

靶标/特异性:

Detects ~58kDa.

推荐稀释度:

WB (1:1000), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.

免疫原:

AA499-509 of Rat PDI

免疫原种属:

Rat

克隆性:

Polyclonal

纯化方式:

Protein A purified

偶联:

FITC

产品浓度:

1 mg/ml

保存温度:

Conjugated antibodies should be stored according to the product label

运输温度:

Blue Ice or 4ºC

存储溶液:

PBS pH7.4, 50% glycerol, 0.09% sodium azide *Storage buffer may change when conjugated

产地:

加拿大

功能与背景:

The three dimensional structure of many extracellular proteins is stabilized by the formation of disulphide bonds. Studies suggest that a microsomal enzyme known as Protein Disulphide Isomerase (PDI) is involved in disulphide-bond formation via its oxidase activity and isomerization via its isomerase activity, as well as the reduction of disulphide bonds in proteins (1). Studies suggest BiP and PDI work together sequentially to increase oxidation of these proteins (2, 3). PDI has also been found to function as a chaperone to prevent the aggregation of unfolded substrates, and serves as a subunit of prolyl 4-hydroxylase and microsomal triglyceride transferase (4, 5). PDI is an abundant 55kDa protein located primarily in the ER, however studies have also proved its presence in the cytosol (1). PDI has the ability to reside in the ER permanently due to the highly conserved KDEL sequence at its carboxy-terminus (6). It uses carboxy-terminal KDEL as a retention signal, and this appears to be sufficient to reduce the secretion of proteins from the ER. This retention is reported to be mediated by a KDEL receptor (7).