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折扣/货期| 货号：AG-CP3-7008-M005 | 规格：5 mg | 目录价：￥1200 |
| 货号：AG-CP3-7008-M025 | 规格：25 mg | 目录价：￥4800 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
Phosphoramidon . disodium salt
别名:
N-[N-[[(6-Deoxy-alpha-L-mannopyranosyl)oxy]hydroxyphosphinyl]-L-leucyl]-L-tryptophan disodium salt; NSC 694280
产品描述:
Phosphoramidon is a potent, reversible and competitive inhibitor of multiple soluble and membrane-bound zinc metalloproteases, particularly gluzincins, such as neutral endopeptidase NEP (Neprilysin; CD10; EC 3.4.24.11) (Ki = 2nM), NEP2 (Neprilysin-2) (Ki ~ 2nM), or endothelin-converting enzyme (ECE) (IC50 = 0.68µM). It inhibits the thermostable neutral metalloproteinase enzyme thermolysin and the integral membrane protein zinc metalloprotease ZMPSTE24. It has little or no effect on a variety of other proteases, including trypsin, papain, chymotrypsin, pepsin and angiotensin-converting enzyme. Shows anti-inflammatory, anti-neurodegenerative and cardioprotective properties. Blocks through NEP degradation of amyloid beta peptides and increases Abeta levels in rodents, indicating that abnormal amyloid processing in Alzheimer's disease may be carried out by a metalloendopeptidase. Plays also a role in the regulation of neuropeptide signaling and in the metabolism of bioactive peptides, such as bradykinin, neurotensin and enkephalin, via plasma membranes. Blocks the formation of endothelin-1, a proinflammatory mediator implicated in the pathogenesis of a variety of lung diseases.
宿主来源:
Synthetic. Originally isolated from Streptomyces tanashiensis.
保存温度:
+4°C
运输温度:
Ambient
预期分子量:
541.5 . 46.0
产品形式:
solid
有效期:
Stable for at least 2 years after receipt when stored at -20°C.
产地:
瑞士
纯度:
>98% (HPLC)
CAS号:
164204-38-0
分子式:
C23H32N3O10P . 2Na
溶解度:
Soluble in water (25mg/ml) or DMSO (10mg/ml).
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