Phosphoramidon . disodium salt-其他小分子化合物-深圳欣博盛生物科技有限公司

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Phosphoramidon . disodium salt

品牌：Adipogen

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说明书

折扣/货期

货号：AG-CP3-7008-M005	规格：5 mg	目录价：￥1200
货号：AG-CP3-7008-M025	规格：25 mg	目录价：￥4800

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

Phosphoramidon . disodium salt

别名:

N-[N-[[(6-Deoxy-alpha-L-mannopyranosyl)oxy]hydroxyphosphinyl]-L-leucyl]-L-tryptophan disodium salt; NSC 694280

产品描述:

Phosphoramidon is a potent, reversible and competitive inhibitor of multiple soluble and membrane-bound zinc metalloproteases, particularly gluzincins, such as neutral endopeptidase NEP (Neprilysin; CD10; EC 3.4.24.11) (Ki = 2nM), NEP2 (Neprilysin-2) (Ki ~ 2nM), or endothelin-converting enzyme (ECE) (IC50 = 0.68µM). It inhibits the thermostable neutral metalloproteinase enzyme thermolysin and the integral membrane protein zinc metalloprotease ZMPSTE24. It has little or no effect on a variety of other proteases, including trypsin, papain, chymotrypsin, pepsin and angiotensin-converting enzyme. Shows anti-inflammatory, anti-neurodegenerative and cardioprotective properties. Blocks through NEP degradation of amyloid beta peptides and increases Abeta levels in rodents, indicating that abnormal amyloid processing in Alzheimer's disease may be carried out by a metalloendopeptidase. Plays also a role in the regulation of neuropeptide signaling and in the metabolism of bioactive peptides, such as bradykinin, neurotensin and enkephalin, via plasma membranes. Blocks the formation of endothelin-1, a proinflammatory mediator implicated in the pathogenesis of a variety of lung diseases.

宿主来源:

Synthetic. Originally isolated from Streptomyces tanashiensis.

保存温度:

+4°C

运输温度:

Ambient

预期分子量:

541.5 . 46.0

产品形式:

solid

产地:

瑞士