Loxistatin acid [E-64c]-其他小分子化合物-深圳欣博盛生物科技有限公司

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Loxistatin acid [E-64c]

品牌：Adipogen

官网链接

说明书

折扣/货期

货号：AG-CP3-7007-M001	规格：1 mg	目录价：￥720
货号：AG-CP3-7007-M005	规格：5 mg	目录价：￥2880

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

Loxistatin acid [E-64c]

别名:

Ep 475; 2S,3S-trans-(Carboxyoxirane-2-carbonyl)-L-leucine-(3-methylbutyl) amide; NSC 694279

产品描述:

E-64c is a potent cell-impermeable epoxysuccinyl peptide inhibitor of calpain and other cysteine proteases, such as papain, cathepsin B, H and L. Does not inhibit the serine proteases trypsin, chymotrypsin or elastase. E-64c is an active metabolite of the protease inhibitor E-64d (Prod. No. AG-CR1-3737), and a synthetic analog of E-64 (Prod. No. AG-CP3-7006). Studies indicate that E-64c is a more potent inhibitor of cathepsins B and L compared to E-64. E-64c has in vitro antiviral, antiparasitic and immunomodulatory properties. It reduces the autocatalytic activity of the foot-and-mouth-disease virus (FMDV) leader protease, reduces infection of HEK293T cells by an HIV-based virus system pseudotyped with SARS-CoV spike glycoprotein in a concentration-dependent manner, inhibits human rotavirus replication, and exhibits entry-blocking effects against MERS-CoV. It also inhibits the trypanosomal cysteine protease cruzain. Significantly reduces calpain-mediated depletion of microtubule-associated protein (MAP2) in an animal model of an ischemic brain.

宿主来源:

Synthetic.

保存温度:

+4°C

运输温度:

Ambient

预期分子量:

314.4

产品形式:

solid

产地:

瑞士