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折扣/货期| 货号：CDX-P0733-M010 | 规格：10 mg | 目录价：￥784 |
| 货号：CDX-P0733-M050 | 规格：50 mg | 目录价：￥3150 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
Pioglitazone hydrochloride
别名:
5-[[4-[2-(5-Ethyl-2-pyridinyl)ethoxy]phenyl]methyl]-2,4-thiazolidinedione monohydrochloride; U 72107A
产品描述:
Pioglitazone hydrochloride is a proliferator-activated receptor gamma (PPARgamma) agonist (EC50 = ~500-600nM for both human and murine PPARgamma) and thiazolidinedione (TZD) anti-diabetic. Pioglitazone is a selective agonist of the nuclear receptor peroxisome proliferator-activated receptor gamma (PPAR-gamma) and to a lesser extent PPAR-alpha. Pioglitazone hydrochloride is usually used to treat type-II diabetes in vivo and has the ability to block hepatic gluconeogenesis. Pioglitazone inhibits pyruvate oxidation and glucose production in hepatocytes when used at a concentration of 10 µM. In vivo, pioglitazone (0.3-3mg/kg per day) reduces hyperglycemia, hyperlipidemia, and hyperinsulinemia in a dose-dependent manner in male Wistar fatty rats. It shos also anti-inflammatory and anti-arteriosclerosis effects.
宿主来源:
Synthetic
保存温度:
+20°C
运输温度:
Ambient
预期分子量:
392.9
产品形式:
solid
产地:
瑞士
纯度:
>98% (HPLC)
CAS号:
112529-15-4
分子式:
C19H20N2O3S . HCl
促销活动
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