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折扣/货期| 货号：CDX-P0921-M250 | 规格：250 mg | 目录价：￥4900 |
| 货号：CDX-P0921-M500 | 规格：500 mg | 目录价：￥7350 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
Piperlongumine (natural)
别名:
Piplartine; 5,6-Dihydro-1-(1-oxo-3-[3,4,5-trimethoxyphenyl]-trans-2-propenyl)-2[1H]-pyridinone
产品描述:
Piperlongumine is a cell-permeable, orally bioavailable natural product isolated from the plant species, Piper longum L, which selectively induces cell death in cancer cells that express both wild-type and mutant p53 but not in primary normal cells and non-transformed immortalized cells. Piperlongumine enhances wild-type p53 and PUMA expression, and inhibits the expression of several pro-survival proteins, including BCL2, surviving, and XIAP, in various types of cancer cells, but not in normal cells. It induces ROS and apoptosis in several human cancer cells (EJ, MDA-MB-231, U2OS and MDA-MB-435), possibly through interaction with oxidative stress responders such as GSTP1 and CBR1. Additionally, it exhibits anti-tumour effects and inhibits the formation of blood vessels in xenograft-tumour mice and inhibits tumor growth and their associated metastases in a MMTV-PyVT breast cancer transgenic mouse model (2.4mg/kg, daily for two weeks, i.p.). Piperlongumine possesses ant-inflammatory, antibacterial, antiangiogenic, antioxidant, anticancer, antiplatelet, anxiolytic, antidepressant and antidiabetic activities.
宿主来源:
Plant
保存温度:
+20°C
运输温度:
Ambient
预期分子量:
317.34
产品形式:
solid
产地:
瑞士
纯度:
>98% (HPLC)
CAS号:
20069-09-4
分子式:
C17H19NO5
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