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折扣/货期| 货号：AG-CR1-2903-M001 | 规格：1 mg | 目录价：￥480 |
| 货号：AG-CR1-2903-M005 | 规格：5 mg | 目录价：￥1020 |
| 货号：AG-CR1-2903-M025 | 规格：25 mg | 目录价：￥2880 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
Purvalanol A
别名:
2-(1R-Isopropyl-2-hydroxyethylamino)-6-(3-chloroanilino)-9-isopropylpurine; NG 60
产品描述:
Potent, cell permeable cyclin-dependent protein kinase (cdk) inhibitor. Inhibits human CDK1 (IC50=4nM), CDK2/cyclin A (IC50=70nM), Cdc2/cyclin B, CDK2/cyclin E (IC50=35nM), CDK4/cyclin D1 (IC50=850nM) as well as CDK5/p35 (IC50=75nM). DYRK1A inhibitor (IC50=300nM). Anticancer agent. Strong apoptotic and autophagy inducer which causes cell cycle arrest in the G1 and G2 phase in various cancer cell lines. More membrane permeable than purvalanol B. Shown to inhibit ABCB1 and ABCB2 transporters and useful in co-treatment with selected anticancer drugs.
保存温度:
+4°C
运输温度:
Ambient
预期分子量:
388.9
产品形式:
solid
产地:
瑞士
纯度:
>98% (HPLC)
CAS号:
212844-53-6
分子式:
C19H25ClN6O
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