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折扣/货期| 货号：SYN-1003-M001 | 规格：1 mg | 目录价：￥1358 |
| 货号：SYN-1003-M005 | 规格：5 mg | 目录价：￥2870 |
| 货号：SYN-1003-M010 | 规格：10 mg | 目录价：￥4690 |
| 货号：SYN-1003-M050 | 规格：50 mg | 目录价：￥13454 |
| 货号：SYN-1003-M100 | 规格：100 mg | 目录价：￥询价 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
Quizartinib
别名:
AC220
产品描述:
Quizartinib (AC220) is a second-generation FLT3 inhibitor that has shown promising activity in AML in Phase II clinical trials. It inhibits mutant and wild-type FLT3 in vivo at 0.1 and 0.5µM, respectively, and has shown favorable activity and tolerability in phase I and II trials in acute myeloid leukemia, with QT prolongation as the dose-limiting toxicity. Recently, AC220 has also been shown to be an effective inhibitor of ATP-binding cassette (ABC) proteins ABCB1 (P-glycoprotein) and ABCG2 (breast cancer resistance protein). Quizartinib inhibited transport of fluorescent ABCG2 and ABCB1 substrates in ABCG2- and ABCB1-overexpressing cells in a concentration-dependent manner, from 0.1 to 5µM and from 0.5 to 10µM, respectively, and inhibited [125I]-IAAP photolabeling of ABCG2 and ABCB1 with IC(50) values of 0.07 and 3.3µM, respectively.
保存温度:
+4°C
运输温度:
Ambient
预期分子量:
560.7
产品形式:
solid
有效期:
Stable for at least 2 years after receipt when stored at -20°C.
产地:
瑞士
纯度:
>95%
CAS号:
950769-58-1
分子式:
C29H32N6O4S
溶解度:
Soluble in DMSO. Slightly soluble (<1mg/ml) in ethanol.
促销活动
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