Quizartinib-其他小分子化合物-深圳欣博盛生物科技有限公司

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Quizartinib

品牌：Adipogen

官网链接

说明书

折扣/货期

货号：SYN-1003-M001	规格：1 mg	目录价：￥1358
货号：SYN-1003-M005	规格：5 mg	目录价：￥2870
货号：SYN-1003-M010	规格：10 mg	目录价：￥4690
货号：SYN-1003-M050	规格：50 mg	目录价：￥13454
货号：SYN-1003-M100	规格：100 mg	目录价：￥询价

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

Quizartinib

别名:

AC220

产品描述:

Quizartinib (AC220) is a second-generation FLT3 inhibitor that has shown promising activity in AML in Phase II clinical trials. It inhibits mutant and wild-type FLT3 in vivo at 0.1 and 0.5µM, respectively, and has shown favorable activity and tolerability in phase I and II trials in acute myeloid leukemia, with QT prolongation as the dose-limiting toxicity. Recently, AC220 has also been shown to be an effective inhibitor of ATP-binding cassette (ABC) proteins ABCB1 (P-glycoprotein) and ABCG2 (breast cancer resistance protein). Quizartinib inhibited transport of fluorescent ABCG2 and ABCB1 substrates in ABCG2- and ABCB1-overexpressing cells in a concentration-dependent manner, from 0.1 to 5µM and from 0.5 to 10µM, respectively, and inhibited [125I]-IAAP photolabeling of ABCG2 and ABCB1 with IC(50) values of 0.07 and 3.3µM, respectively.

保存温度:

+4°C

运输温度:

Ambient

预期分子量:

560.7

产品形式:

solid

产地:

瑞士

纯度:

>95%