官网链接
折扣/货期| 货号：SYN-1019-M001 | 规格：1 mg | 目录价：￥1204 |
| 货号：SYN-1019-M005 | 规格：5 mg | 目录价：￥1736 |
| 货号：SYN-1019-M010 | 规格：10 mg | 目录价：￥2954 |
| 货号：SYN-1019-M050 | 规格：50 mg | 目录价：￥9828 |
| 货号：SYN-1019-M100 | 规格：100 mg | 目录价：￥询价 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
(R)-BI-2536
别名:
(R)-BI2536
产品描述:
Polo-like kinase 1 (Plk1) is a regulator of the cell cycle that has been implicated in the pathology of many cancers. BI-2536 is a potent and selective small-molecule inhibitor of mammalian Plk1. It has inhibitory activity at subnanomolar concentrations and inhibits tumor growth in multiple tumor lines with IC(50) values below 1µM. BI-2536 also shows an >1,000-fold selectivity for PIK1 versus a large panel of other kinases. BI-2536 also demonstrated low Kd values against sister kinases PLK2 and PLK3. Preclinical studies in human cancer cell lines have shown that BI 2536 disrupts spindle assembly, resulting in mitotic arrest and inducing apoptosis. BI-2536 is currently in clinical trials against several types of solid tumor cancers.
保存温度:
+4°C
运输温度:
Ambient
预期分子量:
521.7
产品形式:
solid
产地:
瑞士
纯度:
>95%
CAS号:
755038-02-9
分子式:
C28H39N7O3
促销活动
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