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折扣/货期| 货号：SYN-1189-M001 | 规格：1 mg | 目录价：￥2870 |
| 货号：SYN-1189-M005 | 规格：5 mg | 目录价：￥5824 |
| 货号：SYN-1189-M010 | 规格：10 mg | 目录价：￥9142 |
| 货号：SYN-1189-M050 | 规格：50 mg | 目录价：￥询价 |
| 货号：SYN-1189-M100 | 规格：100 mg | 目录价：￥询价 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
SAR-020106
别名:
SAR020106
产品描述:
SAR-020106 is an ATP-competitive, potent, and selective CHK1 inhibitor with an IC(50) of 13.3nM on the isolated human enzyme. This compound abrogates an etoposide-induced G(2) arrest with an IC(50) of 55nM in HT29 cells, and significantly enhances the cell killing of gemcitabine and SN38 by 3.0- to 29-fold in several colon tumor lines in vitro and in a p53-dependent fashion. Biomarker studies have shown that SAR-020106 inhibits cytotoxic drug-induced autophosphorylation of CHK1 at S296 and blocks the phosphorylation of CDK1 at Y15 in a dose-dependent fashion both in vitro and in vivo.
保存温度:
+4°C
运输温度:
Ambient
预期分子量:
382.9
产品形式:
solid
有效期:
Stable for at least 1 year after receipt when stored at +4°C.
产地:
瑞士
纯度:
>95%
CAS号:
1184843-57-9
分子式:
C19H19ClN6O
溶解度:
Soluble in DMSO.
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