Selumetinib-其他小分子化合物-深圳欣博盛生物科技有限公司

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Selumetinib

品牌：Adipogen

官网链接

说明书

折扣/货期

货号：AG-CR1-3757-M010	规格：10 mg	目录价：￥300
货号：AG-CR1-3757-M050	规格：50 mg	目录价：￥840

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

Selumetinib

别名:

AZD6244; ARRY-142886; CL 1,040; NSC741O78

产品描述:

Selumetinib is an orally available, potent and selective ATP non-competitive inhibitor of the mitogen-activated protein kinases MEK1 (IC50 = 14 nM) and MEK2 (Kd = 530 nM). MEK1 and MEK2 specifically act downstream of growth factor receptors and the proto-oncogenes Ras and Raf to activate ERK1 and ERK2, often leading to an increase in cell proliferation. It inhibits ERK1/2 phosphorylation (IC50 = 10 nM), but exhibits only weak activity at p38α, MKK6, EGFR, ErbB2 and ERK2. Selumetinib inhibits growth of several tumor cell lines but not normal fibroblast lines and shows potent dose-dependent antitumor activity against a panel of mouse xenograft models of colorectal, pancreatic, liver, skin and lung cancer. It inhibits proliferation and induces differentiation and apoptosis in multiple tumor cell lines and tumor xenograft models, and inhibits proliferation of breast cancer and non-small cell lung cancer cell lines, especially those containing Raf and Ras mutations, respectively.

保存温度:

+4°C

运输温度:

Ambient

预期分子量:

457.7

产品形式:

solid

产地:

瑞士

纯度:

>98% (HPLC)