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折扣/货期| 货号：AG-CR1-3756-M005 | 规格：5 mg | 目录价：￥1080 |
| 货号：AG-CR1-3756-M025 | 规格：25 mg | 目录价：￥4320 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
Merafloxacin
别名:
CI-934; PD 114843; 1-Ethyl-7-(3-((ethylamino)methyl)-1-pyrrolidinyl)-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid
产品描述:
Merafloxacin is a fluoroquinolone broad-spectrum antibacterial compound. It is an inhibitor of bacterial DNA gyrase and Type II DNA topoisomerase. It demonstrated excellent activity against Gram-positive organisms and less potent activity against Gram-negative bacteria. Merafloxacin is a programmed -1 ribosomal frameshifting (-1 PRF) inhibitor of SARS-CoV-2. Frameshift inhibition by merafloxacin is robust to mutations within the pseudoknot region and is similarly effective on -1 PRF of other betacoronaviruses and blocks SARS-CoV-2 replication in Vero E6 cells. The compound reduced viral levels in infected African green monkey VeroE6 cells in a concentration-dependent manner. Merafloxacin showed no cellular toxicity and resulted in a 3 to 4 orders of magnitude reduction of SARS-CoV-2 titer, with IC50 of 4.3 µMu. This compound provides a starting point for high-throughput screening for frameshifting inhibitors as a viable target for therapeutic intervention against SARS-CoV-2.
保存温度:
+4°C
运输温度:
Ambient
预期分子量:
379.4
产品形式:
solid
产地:
瑞士
纯度:
>98% (NMR)
CAS号:
110013-21-3
分子式:
C19H23F2N3O3
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