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折扣/货期| 货号：AG-CN2-0487-M010 | 规格：10 mg | 目录价：￥576 |
| 货号：AG-CN2-0487-M050 | 规格：50 mg | 目录价：￥1920 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
Shikonin
别名:
(+)-Shikonin; (R)-Shikonin; Tokyo Violet; NSC 252844; Isoarnebin 4; C.I. 75535; (R)-5,8-Dihydroxy-2-(1-hydroxy-4-methylpent-3-en-1-yl)naphthalene-1,4-dione
产品描述:
Anticancer compound. Inhibits TNF-alpha-induced and B-16 melanoma-induced angiogenesis. Induces apoptosis and RIP1- and RIP3-dependent necroptosis in several cancer cells. Circumvents cancer antidrug resistance through the necroptosis pathway. Proteasome inhibitor. Autophagy inducer. Topoisomerase I inhibitor. Inhibits glycolysis in cancer cells by inhibiting tumor-specific pyruvate kinase M2 (PKM2). Anti-inflammatory compound. Inhibits leukocyte migration, downregulates chemokine receptor expression, and inhibits HIV-1 replication. Inhibits the activation of NLRP3 and AIM2 inflammasome. Shown to directly target caspase-1 and as a inhibitor of PKM2 to block PKM2-mediated glycolysis that promotes inflammasome activation by modulating EIF2AK2 phosphorylation in macrophages. Antioxidant. Free radical scavenger. Directly inhibits nitric oxide synthase (NOS). Regulator of systemic glucose tolerance, energy balance and adiposity/obesity. Adipogenesis inhibitor. Shown to inhibit fat accumulation in adipocytes. Antibacterial and antifungal agent. Shown to potentially inhibit the 33.8-kDa Main Protease (Mpro)/3C-like Protease of SARS-CoV-2, consequently inhibiting viral transcription and replication and possibly inhibiting spread of COVID-19.
宿主来源:
Isolated from Alkanna sp.
保存温度:
+4°C
运输温度:
Ambient
预期分子量:
288.3
产品形式:
solid
有效期:
Stable for at least 2 years after receipt when stored at -20°C.
产地:
瑞士
纯度:
>98% (HPLC)
CAS号:
517-89-5
分子式:
C16H16O5
溶解度:
Soluble in DMSO or DMF. Sparingly soluble in ethanol, methanol or water.
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