SOD1 (UbetaB) Antibody: APC-多抗-深圳欣博盛生物科技有限公司

首页产品中心多抗

SOD1 (UbetaB) Antibody: APC

品牌：Stressmarq

官网链接

说明书

折扣/货期

货号：SPC-205D-APC

规格：100 µg

目录价：￥4599

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

SOD1 (UbetaB) Antibody: APC

别名:

USOD Antibody, Superoxide dismutase 1 Antibody, SOD Antibody, SOD1 unfolded beta barrel region Antibody

产品描述:

Rabbit Anti-Human SOD1 (UbetaB) Polyclonal

反应种属:

Human | Mouse | Rat

宿主来源:

Rabbit

实验应用:

WB | ICC/IF | ELISA

靶标/特异性:

Recognizes a conformation specific epitope where the beta barrel is unfolded.

推荐稀释度:

WB (1:1000), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.

免疫原:

Within 50 AA of N-terminal region of human SOD1, unfolded beta barrel region

免疫原种属:

Human

克隆性:

Polyclonal

纯化方式:

Peptide Affinity purified

偶联:

APC

产品浓度:

1 mg/ml

保存温度:

Conjugated antibodies should be stored according to the product label

运输温度:

Blue Ice or 4ºC

存储溶液:

PBS, 50% glycerol, 0.09% sodium azide *Storage buffer may change when conjugated

产地:

加拿大

功能与背景:

Superoxide dismutase (SOD) is an endogenously produced intracellular enzyme present in almost every cell in the body (2). It works by catalyzing the dismutation of the superoxide radical O2ˉ to O2 and H2O2, which are then metabolized to H2O and O2 by catalase and glutathione peroxidase (1,4). In general, SODs play a major role in antioxidant defense mechanisms (3). There are two main types of SOD in mammalian cells. One form (SOD1) contains Cu and Zn ions as a homodimer and exists in the cytoplasm. The two subunits of 16 kDa each are linked by two cysteines forming an intra-subunit disulphide bridge (2). Misfolding of SOD1 has been implicated in Amyotrophic lateral sclerosis (ALS). Therefore conformation specific antibodies such as Anti-SOD1 (UbetaB), which targets an unfolded region of the beta barrel of SOD1, are useful for determining the conformation of SOD1 in affected tissues (5). This antibody can be used in conjunction with Anti-SOD1 (EDI) (SPC-206D) which detects an exposed dimer interface (EDI) of SOD1.

Accession #:

CAG46542