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折扣/货期| 货号：AG-CR1-3575V-G001 | 规格：1 g | 目录价：￥7200 |
| 货号：AG-CR1-3575V-M050 | 规格：50 mg | 目录价：￥600 |
| 货号：AG-CR1-3575V-M250 | 规格：250 mg | 目录价：￥2400 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
Suramin . sodium salt
别名:
Germanin; NSC 34936; SK 24728
产品描述:
Potent ATPase inhibitor [1]. Potent competitive inhibitor of reverse transcriptase. Shows anti-HIV activity [2, 3]. Anticancer compound [4, 5, 15]. Protein kinase C (PKC) inhibitor [4]. Potent inhibitor of melanoma heparanase and tumor cell metastasis [6]. Non-specific growth factors inhibitor (including PDGF, EGF, aFGF and bFGF) [7, 16]. TGF-beta1 inhibitor [8]. Topoisomerase I and II inhibitor [9]. Interleukin-1 (IL-1) inhibitor [10]. Interleukin-4 (IL-4) inhibitor [11]. G protein inhibitor [12]. P2X and P2Y purinergic receptor antagonist [13]. Antiangiogenic. Potent VEGF inhibitor [14, 15]. Telomerase inhibitor [17]. Shows adjuvant properties [18]. Regulates ryanodine receptor [19]. Direct adenylyl cyclase inhibitor [20]. Protein synthesis inhibitor [21]. SIRT1 (sirtuin 1) and SIRT5 (sirtuin 5) inhibitor [22, 23]. Immunosuppressive [24]. Antifibrotic agent [25]. Antiparasitic. Antiprotozoal. Athelmintic [26]. Cullin-RING E3 ubiquitin ligase inhibitor [29]. Inhibitor of the STING pathway via the inhibition of cGAMP synthase (cGAS) enzymatic activity [32]. Inhibits SARS-CoV-2 infection in cell culture by blocking early steps (binding/fusion) of the replication cycle. Potentially binds and inhibits nsp12 of SARS-CoV-2, binding to motifs harbouring the RNA-dependent RNA polymerases (RdRps) activity [34, 36]. Inhibits several dsDNA-binding proteins, including cGAS (inhibiting cGAS-STING and TLR9 mediated inflammatory responses), Mcm1040 and DNA topoisomerase II, and most recently also the AIM2 inflammasome. Effective inhibitor of dsDNA-induced inflammation [38].
宿主来源:
Synthetic.
保存温度:
+4°C
运输温度:
Ambient
预期分子量:
1291.2 . 137.9
产品形式:
solid
有效期:
Stable for at least 2 years after receipt when stored at +4°C.
产地:
瑞士
纯度:
>98% (HPLC).
CAS号:
129-46-4
分子式:
C51H34N6O23S6 . 6Na
溶解度:
Soluble in water (50mM) or DMSO (10mM). Sparingly soluble in ethanol.
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