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折扣/货期| 货号：SD8800 | 规格：1 Set | 目录价：￥7590 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
TIGIT Detection Set
反应种属:
Human
宿主来源:
llama
实验应用:
ELISA,IHC-P,ICC,IF,Flow
同种型:
sdab
克隆性:
Monoclonal
纯化方式:
TIGIT Antibodies are affinity chromatography purified via Nickel column. Antibodies are supplied as a His-tagged purified protein. They also contains a myc-tag for detection.
偶联:
Unconjugated
产品浓度:
Antibody 1 mg/mL
保存温度:
TIGIT antibodies should be stored in working aliquots at -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
运输温度:
Dry Ice
产品形式:
Liquid
存储溶液:
TIGIT Antibodies are supplied in PBS.
产地:
美国
生产商:
Prosci
功能与背景:
TIGIT Antibody: The T cell immunoreceptor with Ig and ITIM domains (TIGIT) is a member of the PVR (poliovirus receptor) family of immunoglobin proteins. It is expressed on several classes of T cells including follicular B helper T cells (TFH). TIGIT has been shown to bind PVR with high affinity; this binding is thought to assist interactions between TFH and dendritic cells to regulate T cell dependent B cell responses (1). Similar to other immune checkpoint proteins such as PD-1, TIGIT is upregulated on exhausted T cells in chronic viral infections and cancer. Blockade of both TIGIT and PD-1 pathways leads to tumor rejection in mice suggesting that it may be of therapeutic use against cancer (2).
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