TIGIT Recombinant Protein-其他重组蛋白-深圳欣博盛生物科技有限公司

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TIGIT Recombinant Protein

品牌：ProSci LLC

官网链接

说明书

折扣/货期

货号：96-955

规格：0.1 mg

目录价：￥10126

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

TIGIT Recombinant Protein

别名:

TIGIT,VSIG9,VSTM3

实验应用:

ELISA,WB

表达系统:

HEK293 cells

保存温度:

Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.

运输温度:

Blue Ice

产品形式:

Lyophilized

存储溶液:

Tris with Glycine, Arginine and NaCl, pH7.5

产地:

美国

生产商:

Prosci

功能与背景:

TIGIT (also called T cell immunoreceptor with Ig and ITIM domains) is one newly discovered immune receptor on some percentage of T cells and Natural Killer Cells(NK). It is also identified as WUCAM and Vstm3. TIGIT could bind to CD155(PVR) on dendritic cells(DCs), macrophages, etc. with high affinity, and also to CD112(PVRL2) with lower affinity. TIGIT expressing CD8+ T cells has been shown to be expanded and associated with clinical markers of HIV disease progression in a diverse group of HIV infected individuals. TIGIT and PD-1 has been shown to be over expressed on tumor antigen-sepcific (TA-specific) CD8+ T cells and CD8+ tumor infiltrating lymphocytes (TILs) from individuals with melanoma. Blockade of TIGIT and PD-1 led to increased cell proliferation, cytokine production, and degranulation of TA-specific CD8+ T cells and TIL CD8+ T cells.

纯度:

>95% as determined by SDS-PAGE.

Endotoxin level is less than 0.1 EU per ug by the LAL method.

生物活性:

Measured by its binding ability in a functional ELISA. Immobilized Human CD155, Fc Tag at 5 ug/mL (100 uL/well) can bind Human TIGIT, mouse IgG2a Fc tag with a linear range of 3.9-62.5 ng/mL.

Accession #:

AAI01290

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