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折扣/货期| 货号：40-239-0.005 mg | 规格：0.005 mg | 目录价：￥3783 |
| 货号：40-239-0.025 mg | 规格：0.025 mg | 目录价：￥5674.5 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
TLR-3 Recombinant Protein
别名:
CD283, IIAE2, Toll-like receptor 3
表达系统:
HEK293 cells
保存温度:
The lyophilized TLR-3 recombinant protein is stable for at least 2 years from date of receipt at -20˚C. Reconstituted TLR-3 is stable for at least 3 months when stored in working aliquots with a carrier protein at -20˚C. As with any protein, exposing TLR-3 recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
运输温度:
Blue Ice
产品形式:
Lyophilized
产地:
美国
生产商:
Prosci
功能与背景:
TLR-3 is a single-pass type I receptor that binds to and signals the presence of microbial pathogens and double stranded RNA (dsRNA) viruses. Signaling through TLR-3 can promote the NF-κB pathway to initiate innate and adaptive immune responses to bacterial and viral infections, as well as the p53 pathway to trigger apoptosis in cells infected with dsRNA viruses. TLR-3 belongs to a family of structurally-related toll-like receptors (TLRs) containing an N-terminal domain rich in leucine repeats and a C-terminal intracellular Toll/interleukin (IL)-1 (TIL) domain. TLR-3 is expressed primarily in dendritic cells of the placenta and pancreas where it can reside on both sides of the plasma membrane and in the endosomal compartment of the cells. Recombinant human TLR-3 is 77.0 kDa glycoprotein containing 681 residues which comprise the TLR-3 extracellular domain.
纯度:
Greater than 95% by SDS-PAGE gel and HPLC analyses.
Endotoxin level is less than 0.1 ng per μg (1EU/μg).
Endotoxin level is less than 0.1 ng per μg (1EU/μg).
生物活性:
Biological activity was determined by its ability to neutralize Poly I:C induced NF-kappa beta signaling in HT-29 cells stably transfected with NF-kappa beta-luc. The ED50 for this effect is 5-10 ug/ml.”
Accession #:
NP_003256.1
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