Tozasertib-其他小分子化合物-深圳欣博盛生物科技有限公司

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Tozasertib

品牌：Adipogen

官网链接

说明书

折扣/货期

货号：SYN-1092-M001	规格：1 mg	目录价：￥756
货号：SYN-1092-M005	规格：5 mg	目录价：￥980
货号：SYN-1092-M010	规格：10 mg	目录价：￥1134
货号：SYN-1092-M050	规格：50 mg	目录价：￥3332
货号：SYN-1092-M100	规格：100 mg	目录价：￥询价

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

Tozasertib

别名:

MK-0457; VX-680

产品描述:

In mammals, three Aurora kinases, Aurora A, Aurora B, and Aurora C, are expressed. Aurora C expression is mainly restricted to testis, where it functions during meiosis, whereas Aurora A and B play key functions regulating mitosis. Aurora A is localized to the centrosome and spindle poles, where it drives centrosome maturation, separation, and bipolar spindle assembly. Aurora B is the central component of the chromosomal passenger complex (CPC) that also contains the inner centromere protein (INCENP), borealin, and survivin. These non-enzymatic components of the CPC play a key role in regulating kinase activity and localization. Over-expression of Aurora kinases can be oncogeneic and they have thus long been targets for cancer thearpy. Tozasertib, or VX-680, is a potent and selective inhibitor of Aurora kinases, particularly Aurora A and B. In vitro, VX-680 blocks cell cycle progression and induces apoptosis in a wide range of human tumor types at low IC(50) values (i.e. 3.38nM for human BE-13 cells, and 14.34nM for NTERA cells). Moreover, VX680, also has very potent Ki values, with inhibition constants (Ki) of 0.6, 18, and 46nM for Aurora A, B, and C, respectively. VX-680 is also effective in vivo, being used in a Caki-1 xenograft model, VX-680 demonstrated a 75.7% (P < 0.001) decrease in Caki-1 xeno-graft tumor volume with no apparent alternation in animal body weight, peripheral blood counts, or other biological parameters.

保存温度:

+4°C

运输温度:

Ambient

预期分子量:

464.6

产品形式:

solid

产地:

瑞士

纯度:

>95%