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折扣/货期| 货号：SIH-397-25MG | 规格：25 mg | 目录价：￥7012.8 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
Tunicamycin
别名:
Tunicamycin from Streptomyces sp.
产品描述:
Autophagy inducer
保存温度:
-20ºC
运输温度:
Shipped Ambient
预期分子量:
844.95
产品形式:
White solid.
产地:
加拿大
功能与背景:
As a nucleoside antibiotic, Tunicamycin blocks the formation of protein N-glycosidic linkages by inhibiting the transfer of N-acetylglucosamine 1-phosphate to dolichol monophosphate. This causes an induction of glucose-regulated protein 78 (GRP78) mRNA expression, which in turn increases ER stress and subsequently induces autophagy (1-4). Triggers a-synuclein oligomerization, dopaminergic neurons death and locomotor impariement, potentially a model for Parkinson's Disease (5).
纯度:
>98% (HPLC) as a mixture of tunicamycin A, B, C and D
来源:
Isolated from Streptomyces lysosuperficus
CAS号:
11089-65-9
分子式:
C39H64N4O16
溶解度:
Soluble in DMSO (>10 mg/ml) or ethanol (5 mg/ml; warm).
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