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折扣/货期| 货号：AG-CR1-3704-5001 | 规格：5 x 1 mg | 目录价：￥1080 |
| 货号：AG-CR1-3704-M001 | 规格：1 mg | 目录价：￥360 |
| 货号：AG-CR1-3704-M010 | 规格：10 mg | 目录价：￥1140 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
UBS109
别名:
(3E,5E)-1-Methyl-3,5-bis(2-pyridinylmethylene)-4-piperidinone; Monocarbonyl Analog of Curcumin
产品描述:
Most water soluble synthetic monocarbonyl analog of curcumin (MAC) for in vitro and in vivo application. Potently inhibits NF-kappaB and its nuclear translocation by suppressing IKK-alpha and IKK-beta, consequently leading to apoptosis. Potent DNA hypomethylating agent. Inhibits HSP90 and NF-kappaB leading to downregulation of DNA methyltransferase-1 (DNMT-1) expression. Cytotoxic against several cancers in vitro and in vivo. Shows excellent activity against xenografts of head and neck squamous cell carcinoma, pancreatic cancer, colon cancer and breast cancer. Antiangiogenic agent. Induces the downregulation of HIF-1alpha, HSP90, COX-2 and VEGF in tumor samples from xenograft models compared to untreated xenografts. Shows preventive effects on bone loss induced by breast cancer cell bone metastasis. Found to have a potential stimulating effect on osteoblastogenesis and a suppressive effect on osteoclastogenesis in vitro through Smad activation and NF-kappaB inhibition. May have promise in the development into an antiosteoporotic agent capable of promoting new bone formation while simultaneously reducing bone resorption.
保存温度:
+4°C
运输温度:
BI
预期分子量:
291.4
产品形式:
solid
产地:
瑞士
纯度:
>95% (HPLC)
CAS号:
1258513-40-4
分子式:
C18H17N3O
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