YM-254890-其他小分子化合物-深圳欣博盛生物科技有限公司

首页产品中心其他小分子化合物

YM-254890

品牌：Adipogen

官网链接

说明书

折扣/货期

货号：AG-CN2-0509-M001	规格：1 mg	目录价：￥4560
货号：AG-CN2-0509-MC05	规格：500 ug	目录价：￥2520

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

YM-254890

别名:

QS 3666A

产品描述:

Cyclic depsipeptide composed of unique amino acids differing from normal amino acids. Membrane permeable, potent and selective Galphaq family inhibitor. Acts in both in vivo and in vitro systems. Inhibits the signal transduction of Galphaq, Galpha11 and Galpha14 (IC50=0.095µM) by blocking the exchange of GDP for GTP, preventing the activation of the G protein. Inhibits platelet aggregation induced by ADP. Shown to inhibit Galphaq-coupled GPCR signaling by inhibiting calcium mobilization and to have antithrombotic and thrombolytic effects. Might be used as a starting point for new approaches in cancer drug discovery. Galphaq signaling has been shown to regulate brown/beige adipocytes using the structurally similar specific Galphaq family inhibitor FR900359. It is suggested that inhibition of this pathway may be a novel therapeutic approach to combat obesity. The closely related compounds YM-254890 and FR900359 (UBO-QIC) are both potent and selective Galphaq family inhibitors and were for long time only restricted accessible. The commercial availability of YM-254890 might give further insights into Galphaq family signaling processes.

宿主来源:

Isolated from Chromobacterium sp. QS3666 strain.

保存温度:

+4°C

运输温度:

Ambient

预期分子量:

960.1

产品形式:

solid

产地:

瑞士