Ascomycin (high purity)-其他小分子化合物-深圳欣博盛生物科技有限公司

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Ascomycin (high purity)

品牌：Adipogen

官网链接

说明书

折扣/货期

货号：AG-CN2-0420-M001	规格：1 mg	目录价：￥360
货号：AG-CN2-0420-M005	规格：5 mg	目录价：￥600
货号：AG-CN2-0420-M025	规格：25 mg	目录价：￥1680

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

Ascomycin (high purity)

别名:

Immunomycin; FK520; Analog of FK-506; FR-900520; L-683590; NSC 106410; WS 7238A

产品描述:

Macrolide antibiotic. Ethyl analog of FK506 [1, 2]. Strong immunosuppressant. Binds to the FK-506-binding protein FKBP12. This complex inhibits calcineurin (protein phosphatase 2B (PP2B)) [2-4, 8]. Suppresses the production of T helper type 1 (Th1) (interferon and IL-2) and Th2 (IL-4 and IL-10) cytokines in T lymphocytes and preferentially inhibits the activation of mast cells [5-7]. Anti-inflammatory. Used for topical treatment of inflammatory skin diseases [5, 6]. Potently inhibits anti-IgE-induced histamine and cytokine release and reduces IgE-dependent p38 MAPK activation in human basophils. Inhibits basophil degranulation at the initial phase of allergic skin reactions [7, 8]. Antifungal [1]. Antimalaria compound [9]. Anticonvulsant (antiepileptic) [10, 11].

宿主来源:

Isolated from Streptomyces sp.

保存温度:

+4°C

运输温度:

Ambient

预期分子量:

792

产品形式:

solid

有效期:

Stable for at least 2 years after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.