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折扣/货期| 货号：AG-CN2-0420-M001 | 规格：1 mg | 目录价：￥360 |
| 货号：AG-CN2-0420-M005 | 规格：5 mg | 目录价：￥600 |
| 货号：AG-CN2-0420-M025 | 规格：25 mg | 目录价：￥1680 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
Ascomycin (high purity)
别名:
Immunomycin; FK520; Analog of FK-506; FR-900520; L-683590; NSC 106410; WS 7238A
产品描述:
Macrolide antibiotic. Ethyl analog of FK506 [1, 2]. Strong immunosuppressant. Binds to the FK-506-binding protein FKBP12. This complex inhibits calcineurin (protein phosphatase 2B (PP2B)) [2-4, 8]. Suppresses the production of T helper type 1 (Th1) (interferon and IL-2) and Th2 (IL-4 and IL-10) cytokines in T lymphocytes and preferentially inhibits the activation of mast cells [5-7]. Anti-inflammatory. Used for topical treatment of inflammatory skin diseases [5, 6]. Potently inhibits anti-IgE-induced histamine and cytokine release and reduces IgE-dependent p38 MAPK activation in human basophils. Inhibits basophil degranulation at the initial phase of allergic skin reactions [7, 8]. Antifungal [1]. Antimalaria compound [9]. Anticonvulsant (antiepileptic) [10, 11].
宿主来源:
Isolated from Streptomyces sp.
保存温度:
+4°C
运输温度:
Ambient
预期分子量:
792
产品形式:
solid
产地:
瑞士
纯度:
>98%
CAS号:
104987-12-4
分子式:
C43H69NO12
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