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折扣/货期| 货号：AG-CR1-3754-M001 | 规格：1 mg | 目录价：￥240 |
| 货号：AG-CR1-3754-M005 | 规格：5 mg | 目录价：￥600 |
| 货号：AG-CR1-3754-M010 | 规格：10 mg | 目录价：￥960 |
| 货号：AG-CR1-3754-M050 | 规格：50 mg | 目录价：￥3000 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
VX-745
别名:
5-(2,6-Dichlorophenyl)-2-(2,4-difluorophenylthio)-6H-pyrimido[1,6-b]pyridazin-6-one; Neflamapimod; VX745
产品描述:
VX-745 is a potent inhibitor of p38alpha MAPK (IC50=10nM) with 20-fold selectivity over p38beta and 1000-fold selectivity over closely related kinases, ERK1, MK2 and JNK1-3. p38alpha is a member of the mitogen-activated protein kinase (MAPK) family of serine/threonine protein kinases and is widely expressed in endothelial, immune or inflammatory cells and plays a central role in the regulation of proinflammatory cytokine production including TNF-alpha, IL-1beta and IL-6. VX-745 is an anti-inflammatory agent that blocks IL-1beta and TNF-alpha release in whole blood in vitro with IC50 values of 150 and 180nM, respectively. VX-745 showed anti-inflammatory efficacy in an animal model of rheumatoid arthritis and recently anti-neuroinflammatory potential in prevention of early-stage Alzheimers diseases (AD).
保存温度:
+4°C
运输温度:
Ambient
预期分子量:
436.3
产品形式:
solid
产地:
瑞士
纯度:
>95%
CAS号:
209410-46-8
分子式:
C19H9Cl2F2N3OS
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