E-64-其他小分子化合物-深圳欣博盛生物科技有限公司

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E-64

品牌：Adipogen

官网链接

说明书

折扣/货期

货号：AG-CP3-7006-M005	规格：5 mg	目录价：￥540
货号：AG-CP3-7006-M025	规格：25 mg	目录价：￥2160
货号：AG-CP3-7006-M100	规格：100 mg	目录价：￥7560

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

E-64

别名:

L-trans-Epoxysuccinyl-leucylamide-(4-guanido)-butane; N-[N-(L-3-trans-Carboxyoxirane-2-carbonyl]-L-leucyl)-agmatine

产品描述:

The epoxysuccinyl peptide E-64 is an irreversible, potent, and highly selective cysteine protease inhibitor. It inhibits a variety of cysteine proteases, including cathepsins K, L, S, B and H. It inhibits also papain, calpain, ficin and bromelain. Acts by forming a thioether bond with the thiol of the active cysteine. Does not inhibit serine proteases (except reversible inhibition of trypsin) like other cysteine protease inhibitors, e.g. leupeptin and antipain. E-64 is a very useful cysteine protease inhibitor for use for in vitro and in vivo studies because it shows specific inhibition, it is permeable in cells and tissues and has low toxicity. Shown to have diverse biological activities, such as antiviral (FDMV, ASFV), antiparasitic, anticancer and immunomodulatory properties. Shown to reduce bone resorption in embryonic mouse bone explants. Reduces HSC-3 tongue cancer cell invasion and induces oxidative stress and apoptosis in filarial parasites. Inhibits autophagy-associated lysosomal degradation in vitro. E-64 is an effective ligand for affinity purification of cysteine proteases. When coupled to a thiolated affinity matrix, binding is no longer irreversible, but specificity is retained.

宿主来源:

Synthetic. Originally isolated from Aspergillus japonicus.

保存温度:

+4°C

运输温度:

Ambient

预期分子量:

357.4

产品形式:

solid

有效期:

Stable for at least 2 years after receipt when stored at -20°C.