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折扣/货期| 货号：AG-CR1-3662-M001 | 规格：1 mg | 目录价：￥660 |
| 货号：AG-CR1-3662-M005 | 规格：5 mg | 目录价：￥2640 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
FINDY
别名:
(Z)-5-(4-Methoxy-3-((trimethylsilyl)ethynyl)benzylidene)-2-thioxothiazolidin-4-one
产品描述:
Suppressor of DYKR1A intramolecular Ser97 autophosphorylation. Cell permeable thioxothiazolidinone derivative that specifically targets newly synthesized cellular DYRK1A, but not DYRK1B or DYRK2, for proteasomal degradation by suppressing DYKR1A intramolecular Ser97 autophosphorylation, a necessary event for folding/maturation of newly translated DYRK1A. Highly selective inhibitor for DYKR1A over other DYRK family members. Unlike INDY and other ATP-competitive DYRK inhibitors, ineffective against the kinase activity of DYRK1A, DYRK1B, DYRK2 or DYRK3 (IC50>10µM). Inhibits only GSK3beta, MARK4, PIM1, PIM3, PLK3 by over 75% at 10µM among a panel of 271 kinases. Selectively rescues the developmental defect of Xenopus embryos induced by the overexpression of DYRK1A, but not DYRK1B.
保存温度:
+4°C
运输温度:
Ambient
预期分子量:
347.5
产品形式:
solid
有效期:
Stable for at least 2 years after receipt when stored at -20°C.
产地:
瑞士
纯度:
>98% (HPLC)
CAS号:
1507367-37-4
分子式:
C16H17NO2S2Si
溶解度:
Soluble in DMSO (25mg/ml).
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