官网链接
折扣/货期| 货号：AG-CR1-3661-M005 | 规格：5 mg | 目录价：￥1080 |
| 货号：AG-CR1-3661-M025 | 规格：25 mg | 目录价：￥4320 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
MI-2 [MALT1 Inhibitor]
别名:
2-Chloro-N-[4-[5-(3,4-dichlorophenyl)-3-(2-methoxyethoxy)-1H-1,2,4-triazol-1-yl]phenylacetamide; ALB-H03200218
产品描述:
Highly potent and selective irreversible MALT1 inhibitor (IC50=5.8µM). Binds directly to MALT1 and suppresses protease function. Decreases NF-kappaB activity induced by MALT1. Inhibits cell proliferation and MALT1-mediated cleavage activity. Suppresses human TMD8 and HBL-1 (EC50= ~200nM and ~500nM for HBL-1 and TMD8, respectively) activated B cell-like diffuse large B cell lymphoma (ABC-DLBCL) cell lines in vitro and xenotransplanted mouse ABC-DLBCL tumors in vivo and primary human ABC-DLBCLs ex vivo. In combination with bryostatin 1 displays selective killing of HIV latently infected CD4+ T cells. Inhibits NF-kappaB and NLRP3 inflammasome activation in macrophages. Decreased production of IL-1beta/IL-18 in PMA-differentiated THP-1 cells and bone marrow derived macrophage via suppressing the activation of NF-kappaB and NLRP3 inflammasome.
保存温度:
+4°C
运输温度:
Ambient
预期分子量:
455.7
产品形式:
solid
产地:
瑞士
纯度:
>98%
CAS号:
1047953-91-2
分子式:
C19H17Cl3N4O3
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