Glimepiride-其他小分子化合物-深圳欣博盛生物科技有限公司

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Glimepiride

品牌：Adipogen

官网链接

说明书

折扣/货期

货号：CDX-G0208-M250	规格：250 mg	目录价：￥644
货号：CDX-G0208-G001	规格：1 g	目录价：￥2030

产品详情

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产品名称:

Glimepiride

别名:

trans-3-Ethyl-2,5-dihydro-4-methyl-N-[2-[4-[[[[trans-4-methylcyclohexyl)amino]carbonyl]amino]sulfonyl]phenyl]ethyl]-2-oxo-1H-pyrrole-1-carboxyamide; Amaryl; HOE 490

产品描述:

Glimepiride is a long-acting sulfonylurea antidiabetic agent inhibiting ATP-sensitive potassium (KATP) channels in pancreatic beta-cells, which leads to the release of insulin. In addition, Glimepiride increases the activity of intracellular insulin receptors. Studies conducted on adipocytes and skeletal muscle suggest that Glimepiride induces the PI3 kinase (PI3K) and Akt pathway, along with insulin receptor substrate-1/2 and endothelial nitric oxide synthase and stimulates glucose transporter 1 and 4 (GLUT1/4) expression. Glimepiride also increases osteoblast proliferation and differentiation, which is thought to be related to its ability to activate the PI3K and Akt pathway and exhibits neuroprotective benefit, decreasing expression and activity of BACE1 and amyloid-beta (Abeta) in neurons in a PPARgamma-dependent manner.

宿主来源:

Synthetic.

保存温度:

+20°C

运输温度:

Ambient

预期分子量:

490.62

产品形式:

solid

产地:

瑞士