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折扣/货期| 货号：95-110 | 规格：0.05 mg | 目录价：￥4226.625 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
Integrin alpha 4 Recombinant Protein
别名:
Integrin alpha 4 Antibody: IA4, CD49D, Integrin alpha-4, CD49 antigen-like family member D
实验应用:
ELISA,WB
表达系统:
E. coli
保存温度:
Store in working aliquots at -70˚C. Avoid freeze/thaw cycles. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
运输温度:
Dry Ice
产品形式:
Liquid
存储溶液:
50mM Tris pH7.5, 150mM NaCl, 5 mM MgCl2
产地:
美国
生产商:
Prosci
功能与背景:
The integrin alpha 4 (also known as CD49d and ITGA4) belongs to the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha and beta chains (reviewed in 1). Alpha 4 (4) chain associates with either beta 1 (1) or beta 77) chain. It has been demonstrated that the putative ligand-binding sites of both integrin 41 and 47 is located on the 4 chain. These ligands included Madcam, VCAM, and fibronectin (2-4). Madcam is known as the principal ligand for integrin a4b7. Recently it was also demonstrated that HIV-1 envelope can mimic Madcam by binding to and signaling though integrin 47, the gut mucosal homing receptor for peripheral T cells (5). This recombinant protein fragment includes the ligand and monoclonal antibody binding domains; this binding has been tested and verified in ELISA assays. This recombinant protein is recognized PSI antibodies Integrin 4 (IN1) (PSI 4827) and Integrin 4 (IN2) (PSI 4837), but not Integrin 4 (CT) (PSI 4783).
纯度:
~95%
Accession #:
NP_000876
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