Ketoconazole-其他小分子化合物-深圳欣博盛生物科技有限公司

首页产品中心其他小分子化合物

Ketoconazole

品牌：Adipogen

官网链接

说明书

折扣/货期

货号：CDX-K0016-G001	规格：1 g	目录价：￥1106
货号：CDX-K0016-G005	规格：5 g	目录价：￥4606

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

Ketoconazole

别名:

(±)-cis-1-Acetyl-4-(4-[(2-[2,4-dichlorophenyl]-2-[1H-imidazol-1-ylmethyl]-1,3-dioxolan-4-yl)-methoxy]phenyl)piperazine; R 41400; NSC 317629; BRN 4303081

产品描述:

Ketoconazole is a broad-spectrum triazole antifungal agent that has activity against C. albicans, C. krusei, C. tropicalis, C. glabrata, C. parapsilosis, C. neoformans and A. fumigatus strains (IC50s = 0.031-8 µg/ml). It inhibits the fungal cytochrome P450 (CYP) isoform CYP51, also known as lanosterol 14alpha-demethylase, which arrests ergosterol biosynthesis at the fungal membrane. This interaction inhibits ergosterol synthesis and results in increased fungal cellular permeability. Ketoconazole also inhibits human CYP3A4 (IC50 = 0.54 µM). Formulations containing ketoconazole have been used in the treatment of fungal infections. Ketoconazole blocks in humans activity of several enzymes necessary for the conversion of cholesterol to steroid hormones such as testosterone and cortisol. It has been shown to inhibit cholesterol side-chain cleavage enzyme, which converts cholesterol to pregnenolone, 17alpha-hydroxylase and 17,20-lyase, which convert pregnenolone into androgens, and 11beta-hydoxylase, which converts 11-deoxycortisol to cortisol. All of these enzymes are mitochondrial cytochrome p450 enzymes. Based on these antiandrogen and antiglucocorticoid effects, ketoconazole has been used with some success as a second-line treatment for certain forms of advanced prostate cancer and for the suppression of glucocorticoid synthesis in the treatment of Cushing's syndrome. Ketoconazole displays potent anti-metastatic, anti-neoplastic, and anti-psoriatic activities and acts as an inhibitor of 5-lipoxygenase (5-LO) and thromboxane synthase activities.

保存温度:

+4°C

运输温度:

Ambient

预期分子量:

531.43

产品形式:

solid

产地:

瑞士

纯度:

99.0-101.0% (EP, Titration)