Mubritinib [TAK-165]-其他小分子化合物-深圳欣博盛生物科技有限公司

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Mubritinib [TAK-165]

品牌：Adipogen

官网链接

说明书

折扣/货期

货号：AG-CR1-3755-M005	规格：5 mg	目录价：￥360
货号：AG-CR1-3755-M025	规格：25 mg	目录价：￥1440

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

Mubritinib [TAK-165]

别名:

TAK-165; TAK 165; CID 6444692

产品描述:

Mubritinib (TAK-165) is a selective inhibitor of the human epidermal growth factor receptor 2 (EGFR2; HER2), inhibiting HER2 phosphorylation with an IC50 value of 6nM. It is 4000-fold selective over EGFR, FGFR, PDGFR, JAK1, Src and Blk (IC50 > 25µM). Mubritinib inhibits the proliferation of breast, bladder, kidney and prostate cancer cells in vitro and in vivo. Mubritinib was shown to inhibit autophagy in a HER2-independent manner in cancer cells. Recently Mubritinib has been shown to be a mitochondrial electron transport chain complex I (NADH-CoQ reductase) inhibitor. Mubritinib functions through ubiquinone-dependent inhibition of electron transport chain (ETC) complex I activity and consequently oxidative phosphorylation (OXPHOS). This agent could be useful for immunometabolism research. Inhibition of electron transport chain in mitochondria leads to blocking of the transfer of electrons from iron-sulfur centers in complex I to ubiquinone. By inhibiting the mitochondrial respiratory complex I, this agent reduces cardiac-cell beat rate, with prolonged exposure resulting in cell death. Complex I inhibition is directly linked to anti-cancer cell activity.

保存温度:

+4°C

运输温度:

Ambient

预期分子量:

468.5

产品形式:

solid

产地:

瑞士

纯度:

>95%