深圳欣博盛生物科技有限公司

Metformin Sterile Solution

Metformin Lipodisq Sterile Solution; 1,1-Dimethylbiguanide . HCl; NSC 91485; DMGG; LA 6023

Metformin Lipodisq Sterile Solution is a ready-to-use nano-formulated aqueous solution. Metformin is an antihyperglycemic agent of the biguanide class, used for the management of type II diabetes and is currently prescribed to at least 120 million people worldwide. It is an AMPK activator and a mitochondrial electron transport chain complex I inhibitor, reducing mitochondrial reactive oxygen species (ROS). This antidiabetic and anti-hyperglycemic agent reduces blood glucose levels, improves insulin sensitivity, and decreases insulin resistance. Insulin sensitizer in non-alcoholic fatty liver disease (NAFLD). Increases plasma concentrations of the glucose-lowering gut incretin hormone glucagon-like peptide-1 (GLP-1), which may contribute to metformin’s glucose-lowering effect. An anticancer agent with antiproliferative and proapoptotic activity in cancer cell lines. Autophagy activator. Targets brown adipose tissue (BAT) in vivo and reduces oxygen consumption. Anti-inflammatory agent by inhibition of nuclear factor kappaB (NF-kappaB) via AMPK-dependent and independent pathways. Also described to inhibit NLRP3 inflammasome activation, subsequent caspase-1 cleavage and interleukin-1beta secretion. Since the emergence of SARS-CoV-2, Metformin has been investigated as a prophylactic agent for the prevention of COVID-19. Metformin Lipodisq is based on a nanoparticle (11-40nm) drug delivery system comprising a discoidal phospholipid bilayer membrane stabilized by a chaperone molecule annulus. Internal properties of the phospholipid membrane support the disposition and stabilization of drug molecule candidates and preserve the native conformation of membrane molecules. The resulting encapsulated actives are rendered water-soluble and specialized for intra-cellular penetration/delivery via endosomal uptake mechanisms. Lipodisq solutions show a good safety profile and are suitable for in vitro and in vivo investigations.

1mg/ml (0.1% w/vol)

+4°C

Ambient

129.2 . 36.5

liquid

Liquid, detergent-free discoidal nano-formulation made of styrene-maleic acid lipid particles (SMALP), lecithin and sterile water.

瑞士

>95% (HPLC)

Discoidal nano-particles can incorporate hydrophobic, poorly water-soluble compounds, such as lipids, lipoproteins and glycolipids. - Cell culture tested (human macrophage cell line) (MTT). - Recommended starting dilution: 1:200 or higher. - Optimal working concentrations depend on the applications and need to be determined. - Published procedures using Lipodisq formulations (Curcumin and IAXO TLR4 antagonists) in vivo rodent models at 3-10mg/kg. Recommended route of administration is subcutaneous (s.c.) with oral or nasal application as a possible alternative, which needs to be optimized.

C4H11N5 . HCl