Nintedanib (free base)-其他小分子化合物-深圳欣博盛生物科技有限公司

首页产品中心其他小分子化合物

Nintedanib (free base)

品牌：Adipogen

官网链接

说明书

折扣/货期

货号：CDX-N0321-M025	规格：25 mg	目录价：￥798
货号：CDX-N0321-M100	规格：100 mg	目录价：￥2394

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

Nintedanib (free base)

别名:

BIBF-1120; BIBF1120

产品描述:

Nintedanib is an orally bioavailable and potent triple angiokinase inhibitor with potential antiangiogenic and antineoplastic activities. It targets the proangiogenic pathways mediated by the the receptor tyrosine kinases VEGFR1/2/3 (IC50=13-34nM), FGFR1/2/3 (IC50=37-108nM) and PDGFRalpha/beta (IC50=59-65nM), which may result in the induction of endothelial cell apoptosis, a reduction in tumor vasculature, and the inhibition of tumor cell proliferation and migration. Nintedanib competitively binds to the ATP binding-pocket of these receptors, resulting in interference with receptor dimerization and blocking intracellular signaling critical for the proliferation and survival of angiogenesis-related endothelial cells, pericytes and vascular smooth muscle cells. Nintedanib also inhibits some non-receptor kinases such as Fms-like tyrosine protein kinase (Flt-3, IC50=26nM), proto-oncogene ret (Ret, IC50=35nM), lymphocyte-specific tyrosine kinase (Lck, IC50=16nM), tyrosine-protein kinase lyn (Lyn, IC50=195nM) and proto-oncogene tyrosine protein kinase src (Src, IC50=156nM). Through this unique targeting profile nintedanib has significant antitumor activity in several tumor types.

保存温度:

-20°C

运输温度:

Ambient

预期分子量:

539.6

产品形式:

solid

有效期:

Stable for at least 2 years after receipt when stored at -20°C.

产地:

瑞士