官网链接
折扣/货期| 货号：CDX-N0321-M025 | 规格：25 mg | 目录价：￥826 |
| 货号：CDX-N0321-M100 | 规格：100 mg | 目录价：￥2492 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
Nintedanib (free base)
别名:
BIBF-1120; BIBF1120
产品描述:
Nintedanib is an orally bioavailable and potent triple angiokinase inhibitor with potential antiangiogenic and antineoplastic activities. It targets the proangiogenic pathways mediated by the the receptor tyrosine kinases VEGFR1/2/3 (IC50=13-34nM), FGFR1/2/3 (IC50=37-108nM) and PDGFRalpha/beta (IC50=59-65nM), which may result in the induction of endothelial cell apoptosis, a reduction in tumor vasculature, and the inhibition of tumor cell proliferation and migration. Nintedanib competitively binds to the ATP binding-pocket of these receptors, resulting in interference with receptor dimerization and blocking intracellular signaling critical for the proliferation and survival of angiogenesis-related endothelial cells, pericytes and vascular smooth muscle cells. Nintedanib also inhibits some non-receptor kinases such as Fms-like tyrosine protein kinase (Flt-3, IC50=26nM), proto-oncogene ret (Ret, IC50=35nM), lymphocyte-specific tyrosine kinase (Lck, IC50=16nM), tyrosine-protein kinase lyn (Lyn, IC50=195nM) and proto-oncogene tyrosine protein kinase src (Src, IC50=156nM). Through this unique targeting profile nintedanib has significant antitumor activity in several tumor types.
保存温度:
-20°C
运输温度:
Ambient
预期分子量:
539.6
产品形式:
solid
产地:
瑞士
纯度:
>99% (HPLC)
CAS号:
656247-17-5
分子式:
C31H33N5O4
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