官网链接
折扣/货期| 货号：AG-CN2-0058-C025 | 规格：25 ug | 目录价：￥1080 |
| 货号：AG-CN2-0058-C100 | 规格：100 ug | 目录价：￥2640 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
Okadaic acid . ammonium salt (high purity)
别名:
Halochondrine A; CCRIS 3329; HSDB 7243; 9,10-Deepithio-9,10-didehydroacanthifolicin
产品描述:
Non-phorbol type tumor promoter [1]. Reversible, potent and selective serine threonine protein phosphatase inhibitor. PP2A (IC50=0.2-1nM), PP1 (IC50=3-15nM), PP2B (IC50= >1µM). Does not inhibit PP2C [2, 6, 7, 18]. Stimulates intracellular protein phosphorylation [3]. Useful tool for studying cellular processes that are regulated by phosphorylation. Does not affect activity of acid phosphatase, alkaline phosphatase and tyrosine phosphatase [4, 5]. Mimics the effects of insulin [7]. Activates atypical protein kinase C (zeta/lambda) in 3T3/L1 adipocytes [14, 19]. Enhances transmitter release at neuromuscular junctions [8]. Apoptosis inhibitor [9, 11, 12]. Induces apoptosis in human breast carcinoma cells (MB-231 and MCF-7) and in myeloid cells [10]. Neurotoxic [12, 16]. Used to study various cellular processes including cell cycle, apoptosis, nitric oxide metabolism and calcium signaling [13, 15, 17, 18]. Stimulates cell motility, loss of stabilization of focal adhesions and a consequent loss of cytoskeletal organization [20].
宿主来源:
Isolated from Prorocentrum concavum. Salt form generated in aqueous ammonium hydroxide-methanol solution.
保存温度:
+4°C
运输温度:
Ambient
预期分子量:
804.0 . 18.0
产品形式:
solid
有效期:
Stable for at least 2 years after receipt when stored at -20°C.
产地:
瑞士
纯度:
>98% (HPLC)
CAS号:
175522-42-6
分子式:
C44H67O13 . NH4
溶解度:
Soluble in DMSO, ethanol, methanol, acetone, ethyl acetate or distilled water. Dissolve first in organic solvent before diluting in water.
促销活动
精品推荐
