PARG Inhibitor PDD00017273-其他小分子化合物-深圳欣博盛生物科技有限公司

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PARG Inhibitor PDD00017273

品牌：Adipogen

官网链接

说明书

折扣/货期

货号：AG-CR1-3646-M001	规格：1 mg	目录价：￥840
货号：AG-CR1-3646-M005	规格：5 mg	目录价：￥2160

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

PARG Inhibitor PDD00017273

别名:

PARG Inhibitor Compound 4; 1-[(2,5-Dimethylpyrazol-3-yl)methyl]-N-(1-methylcyclopropyl)-3-[(2-methylthiazol-5-yl)methyl]-2,4-dioxo-quinazoline-6-sulfonamide

产品描述:

Human poly(ADP-ribose) glycohydrolase (PARG) inhibitor for in vitro studies. Inhibits human recombinant PARG enzymes (IC50=26nM) and PARG in cell assays (IC50=37nM). Inactive against related glycohydrolases ARH3 and PARP1s (IC50>30µM). Showed no cytotoxicity (IC50>30µM). Poly(ADP ribose) glycohydrolase (PARG) is a critical component in the repair of single strand DNA breaks and therefore a target in cancer cells. PARG counteracts the function of the ARTD family of poly(ADP ribose) polymerases (known as PARPs) by efficiently catalysing the hydrolysis of O-glycosidic linkages of ADP-ribose polymer, thereby reversing the effects of PARPs.

保存温度:

+4°C

运输温度:

Ambient

预期分子量:

514.6

产品形式:

solid

有效期:

Stable for at least 2 years after receipt when stored at -20°C.

产地:

瑞士