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折扣/货期| 货号：CDX-P0598-M010 | 规格：10 mg | 目录价：￥364 |
| 货号：CDX-P0598-M050 | 规格：50 mg | 目录价：￥1470 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
Pimecrolimus
别名:
Elidel; SDZ-ASM 981; 33-Epichloro-33-desoxyascomycin
产品描述:
Pimecrolimus is a immunosuppressive natural ascomycin macrolactam that binds to macrophilin-12 (FKBP-12) and inhibits calcineurin as well as prolyl isomerase (rotamase). Presumably through these actions, it blocks the activation of T cells by allogeneic dendritic cells (IC50=0.55nM) without affecting dendritic cells. Moreover, pimecrolimus suppresses the generation of pro-inflammatory cytokines by T cells, the release of pre-formed inflammatory mediators from mast cells and the activation of eosinophils. These effects support the use of pimecrolimus in countering inflammatory skin diseases, such as atopic dermatitis (eczema) and psoriasis.
宿主来源:
Synthetic
保存温度:
+4°C
运输温度:
Ambient
预期分子量:
810.45
产品形式:
solid
产地:
瑞士
纯度:
>97% (HPLC)
CAS号:
137071-32-0
分子式:
C43H68ClNO11
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